{"id":98979,"date":"2021-12-15T10:00:39","date_gmt":"2021-12-15T10:00:39","guid":{"rendered":"https:\/\/ujkafe.website\/?p=98979"},"modified":"2021-12-15T11:17:22","modified_gmt":"2021-12-15T11:17:22","slug":"hiret-vettuk-kariko-katalin-biokemikus-mellett-kizzmekia-corbett-barney-graham-es-drew-weissman-lettek-a-time-magazinnal-2021-ben-az-ev-hosei","status":"publish","type":"post","link":"https:\/\/ujkafe.website\/?p=98979","title":{"rendered":"H\u00edr\u00e9t vett\u00fck: Karik\u00f3 Katalin biok\u00e9mikus mellett Kizzmekia Corbett, Barney Graham, \u00e9s Drew Weissman lettek a Time magazinn\u00e1l 2021-ben az \u00e9v h\u0151sei"},"content":{"rendered":"\r\n<p><em><strong>K\u00e9t h\u00f6lgy, k\u00e9t f\u00e9rfi\u00fa \u2013 n\u00e9gy fantasztikus tud\u00f3s, a koronav\u00edrus ellen kifejlesztett vakcin\u00e1k \u00e9lharcosai. A d\u00f6nt\u00e9s nem meglep\u0151, hiszen az idei \u00e9v a koronav\u00edrus ellen v\u00e9dekez\u00e9sr\u0151l \u00e9s a v\u00edrus ellen kifejlesztett vakcin\u00e1kr\u00f3l sz\u00f3lt.<\/strong><\/em><\/p>\r\n<p><a href=\"https:\/\/ujkafe.website\/wp-content\/uploads\/2021\/12\/2021hosei-kariko.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-98981\" src=\"https:\/\/ujkafe.website\/wp-content\/uploads\/2021\/12\/2021hosei-kariko.jpg\" alt=\"\" width=\"449\" height=\"599\" srcset=\"https:\/\/ujkafe.website\/wp-content\/uploads\/2021\/12\/2021hosei-kariko.jpg 510w, https:\/\/ujkafe.website\/wp-content\/uploads\/2021\/12\/2021hosei-kariko-225x300.jpg 225w\" sizes=\"auto, (max-width: 449px) 100vw, 449px\" \/><\/a><\/p>\r\n<p><!--more--><br><br>Kiemelkedik Karik\u00f3 Katalin a biomedicina forradalmas\u00edt\u00f3ja, az emberis\u00e9g j\u00f3tev\u0151je, a leg\u00fajabb magyar csillag a vil\u00e1gtudom\u00e1ny eg\u00e9n. Felfedez\u00e9sei, tudom\u00e1nyos m\u00f3dszerei \u00e9s eredm\u00e9nyei emberis\u00e9g- \u00e9s vil\u00e1gl\u00e9pt\u00e9k\u0171, felm\u00e9rhetetlen t\u00f6rt\u00e9nelmi jelent\u0151s\u00e9g\u0171ek. Tudom\u00e1nyos munk\u00e1ss\u00e1ga \u00edgy foglalhat\u00f3 \u00f6ssze (a Wikip\u00e9dia nyom\u00e1n, hozz\u00e1vet\u0151leges ford\u00edt\u00e1sban):<br><br>2005-ben Drew Weissmannal egy\u00fctt kidolgozta a m\u00f3dos\u00edtott nukleozidokat tartalmaz\u00f3 mRNS ter\u00e1pi\u00e1s alkalmaz\u00e1s\u00e1nak szabadalm\u00e1t, amely lehet\u0151v\u00e9 tette azt, hogy az mRNS ter\u00e1pia alkalmazhat\u00f3 legyen t\u00falzott immunreakci\u00f3k kiv\u00e1lt\u00e1sa n\u00e9lk\u00fcl.<br>T\u00e1rsfeltal\u00e1l\u00f3ja nyolc, az mRNS-sel kapcsolatos szabadalomnak, amit az USA-ban nem immunog\u00e9n, nukleoziddal m\u00f3dos\u00edtott RNS alkalmaz\u00e1s\u00e1ra adtak ki.<br>Az 1980-as \u00e9vek v\u00e9g\u00e9re a tudom\u00e1nyos k\u00f6z\u00f6ss\u00e9g nagy r\u00e9sze a DNS-re koncentr\u00e1lt a g\u00e9nter\u00e1pia megval\u00f3s\u00edt\u00e1sa kapcs\u00e1n, de Karik\u00f3 Katalin \u00fagy v\u00e9lte, hogy az mRNS is \u00edg\u00e9retes lehet ter\u00e1pi\u00e1s felhaszn\u00e1l\u00e1sra, mivel a legt\u00f6bb betegs\u00e9g nem \u00f6r\u00f6kletes, \u00e9s ez\u00e9rt nincs sz\u00fcks\u00e9g olyan megold\u00e1sokra, amelyek v\u00e9glegesen megv\u00e1ltoztatn\u00e1k az ember genetik\u00e1j\u00e1t. A biok\u00e9mikus tud\u00f3st\u00e1rsak m\u00e9ly szkepticizmusa ellen\u00e9re folytatta a kutat\u00e1sait. Kevesen ismert\u00e9k fel, hogy a t\u00e9m\u00e1ban \u00fatt\u00f6r\u0151nek sz\u00e1m\u00edt\u00f3 szabadalom megnyitotta a kaput a biomedicina forradalm\u00e1nak.<br>2006 \u00e9s 2013 k\u00f6z\u00f6tt az RNARx nev\u0171 c\u00e9g t\u00e1rsalap\u00edt\u00f3ja \u00e9s vez\u00e9rigazgat\u00f3ja. 2013-ban a B\u0151rgy\u00f3gy\u00e1szati \u00e9s Venerol\u00f3giai Szeml\u00e9ben megjelent tanulm\u00e1nyban a Debreceni Egyetem \u00e9s az University of Pennsylvania tud\u00f3saival egy\u00fctt meg\u00e1llap\u00edtotta, hogy a k\u00fcl\u00f6nb\u00f6z\u0151 g\u00e9nter\u00e1pi\u00e1ra ir\u00e1nyul\u00f3 elj\u00e1r\u00e1sok k\u00f6z\u00fcl az mRNS haszn\u00e1lata t\u0171nik a legalkalmasabbnak a ter\u00e1pi\u00e1s feh\u00e9rj\u00e9k expressz\u00e1l\u00e1s\u00e1ra, enzimdefektusok jav\u00edt\u00e1s\u00e1ra illetve vakcina k\u00e9sz\u00edtm\u00e9nyek kifejleszt\u00e9s\u00e9re.<br>2020-ban a szabadalma alapj\u00e1n k\u00e9sz\u00fclt el, a vil\u00e1gon els\u0151k\u00e9nt klinikailag is bizony\u00edtottan hat\u00e1sos harmadik gener\u00e1ci\u00f3s Pfizer-BioNTech Covid19-vakcina (Comirnaty vakcina). Kutat\u00e1si eredm\u00e9nyei nyom\u00e1n tudom\u00e1nyos k\u00f6r\u00f6kben t\u00f6bben Nobel-d\u00edj es\u00e9lyesnek \u00edt\u00e9lt\u00e9k \u2013 a brit etol\u00f3gus Richard Dawkins \u00e9pp\u00fagy, mint a kanadai \u0151ssejtbiol\u00f3gus, a Moderna c\u00e9g egyik t\u00e1rsalap\u00edt\u00f3ja, Derrick Rossi -, de egyel\u0151re a d\u00edj v\u00e1rat mag\u00e1ra. A tud\u00f3sok \u00fagy gondolt\u00e1k, hogy a vil\u00e1g els\u0151 g\u00e9ntechnol\u00f3gi\u00e1val m\u00f3dos\u00edtott vakcin\u00e1j\u00e1nak technol\u00f3gi\u00e1ja kihat m\u00e1s betegs\u00e9gek terjed\u00e9s\u00e9nek megakad\u00e1lyoz\u00e1s\u00e1ra, a r\u00e1kt\u00f3l \u00e9s agyv\u00e9rz\u00e9st\u0151l kezdve a mal\u00e1ri\u00e1ig \u00e9s a sclerosis multiplexig.<br>A szabadalmat jegyz\u0151 k\u00e9t kutat\u00f3, Karik\u00f3 Katalin \u00e9s Drew Weissman 2020. december 18-\u00e1n, az University of Pennsylvania \u00e9p\u00fclet\u00e9ben, egy\u00fctt kapta meg a Pfizer\/BioNTech vakcina els\u0151 d\u00f3zis\u00e1t, t\u00f6bb mint 20 \u00e9vvel azut\u00e1n, hogy megkezdt\u00e9k alapvet\u0151 tudom\u00e1nyos egy\u00fcttm\u0171k\u00f6d\u00e9s\u00fcket.<br><br>Forr\u00e1s: <a href=\"https:\/\/www.ujhet.com\/kariko-katalin-negyedmagaval-az-ev-hose-a-vilagon\/\">ujhet.com<\/a><\/p>\r\n<p>&nbsp;<\/p>\r\n","protected":false},"excerpt":{"rendered":"<p>K\u00e9t h\u00f6lgy, k\u00e9t f\u00e9rfi\u00fa \u2013 n\u00e9gy fantasztikus tud\u00f3s, a koronav\u00edrus ellen kifejlesztett vakcin\u00e1k \u00e9lharcosai. A d\u00f6nt\u00e9s nem meglep\u0151, hiszen az idei \u00e9v a koronav\u00edrus ellen v\u00e9dekez\u00e9sr\u0151l \u00e9s a v\u00edrus ellen kifejlesztett vakcin\u00e1kr\u00f3l sz\u00f3lt.<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"ngg_post_thumbnail":0,"footnotes":""},"categories":[8],"tags":[],"class_list":["post-98979","post","type-post","status-publish","format-standard","hentry","category-hir"],"_links":{"self":[{"href":"https:\/\/ujkafe.website\/index.php?rest_route=\/wp\/v2\/posts\/98979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ujkafe.website\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ujkafe.website\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ujkafe.website\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/ujkafe.website\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=98979"}],"version-history":[{"count":0,"href":"https:\/\/ujkafe.website\/index.php?rest_route=\/wp\/v2\/posts\/98979\/revisions"}],"wp:attachment":[{"href":"https:\/\/ujkafe.website\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=98979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ujkafe.website\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=98979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ujkafe.website\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=98979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}